DXA is the gold standard technique used for the management and follow-up of osteoporosis. 3D-SHAPER is a software application that registers a 3D statistical model onto the hip DXA scan of the patient, and uses a model-based algorithm to create a 3D map of the cortical surface density. It allows clinicians to assess the cortical and trabecular macrostructure in 3D from a standard hip DXA scan.

Validation

A multicenter clinical study was performed to compare 3D-SHAPER with Quantitative Computed Tomography (QCT) analyses. Strong correlations were found between measurements performed using the two techniques [1].
Picture: Cortical thickness distribution (left) and frontal slices showing bone density values (right) obtained by 3D-SHAPER and QCT for three patients [1].

Algorithm

Shape Density Model

3D-SHAPER incorporates a statistical model built from a database of quantitative computed tomography scans. The shape and density variations in the first three principal directions are shown [1].

Shape Density Model

3D-SHAPER registers the statistical model onto the DXA projection of the patient. The algorithm maximizes the similarity between the projection of the model and the DXA image [1].

Cortex Cortex Cortex

3D-SHAPER estimates the cortical thickness and density by the fitting a mathematical function onto the density profiles measured along the normal vector at each vertex of the femoral shape [2].

Galgo Medical
Predictive Software for Safer Treatment

Galgo develops 3D medical image post-processing software solutions to add predictive value to personalized treatment strategies. Each patient is different and requires tailored treatment: personalized medication, surgical implants and interventional strategies. The increasing availability of high-quality patient images enables Galgo's algorithms and software to extract key clinical information to support clinical decision-making and planning and guidance of interventional procedures.

Galgo has focused on four medical disciplines:

Intra-cranial aneurysms, to plan, for each patient, the endovascular treatment with braided devices.

Epilepsy, to tailor the implantation of deep electrodes using complex 3D multimodal data.

Arrhythmias, to identify the arrhythmic substrate and to plan catheter ablation procedures from cardiac MRI.

Osteoporosis, to improve disease management by turning DXA images into 3D patient-specific models.

iso 13485
Galgo Medical SL has been certified by BSI to ISO 13485:2012 under certificate number MD 656038.

www.galgomedical.com